| Date | Opponent | Time | Location | Livestream Link | Score | Record |
|
|---|---|---|---|---|---|---|---|
 | Friday, August 27th, 2021 | Lawrenceville Indians | 6:00 pm | Marshall High School | Marshall Lions Livestream | L 35-45 | 0-1 |
| Friday, September 3rd, 2021 | Mt. Carmel Golden Aces | 6:00 pm | Marshall High School | Marshall Lions Livestream | L 0-61 | 0-2 |
| Friday, September 10th, 2021 | South Vermillion Wildcats | 6:00 pm | South Vermillion H.S. | Marshall Lions Livestream | L 6-35 | 0-3 |
| Friday, September 17th, 2021 | Robinson Maroons | 6:30 pm | Robinson High School | Marshall Lions Livestream | L 6-46 | 0-4 |
| Friday, September 24th, 2021 | Olney Tigers | 6:30 pm | Marshall High School | Marshall Lions Livestream | L 24-48 | 0-5 |
| Friday, October 1st, 2021 | Paris Tigers | 6:30 pm | Paris High School | Marshall Lions Livestream | 0-0 | |
| Friday, October 8th, 2021 | Red Hill High School | 6:30 pm | Marshall High School | Marshall Lions Livestream | 0-0 | |
| Friday, October 15th, 2021 | Casey-Westfield Warriors | 6:30 pm | Casey-Westfield H.S. | Marshall Lions Livestream | 0-0 | |
| Friday, October 22nd, 2021 | Newton Eagles | 6:30 pm | Marshall High School | Marshall Lions Livestream | 0-0 |
